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Just in case anyone is concerned about how fast the COVID-19 vaccines were produced: it is because they are variants of the SARS vaccine, which we've had for more than a decade.

COVID-19 can be treated with a variant of the SARS vaccine because COVID-19 is a variant of SARS. The virus that causes SARS is SARS-CoV, and the 2019 novel coronavirus is SARS-CoV-2.

Because of this, researchers had a vaccine ready for testing as early as January 2020. The COVID-19 vaccine had, in fact, nearly a full year of testing and refinement. It is not by any means "experimental" or "untested".

@noelle I'm just glad mRNA vaccine tech actually reached production instead of being dismissed as unprofitable because ~ c a p i t a l i s m ~ and we can use it to combat HIV and other things

The price in lives was far higher than any justification capitalists can make for not producing it sooner, but that blood's on their hands :/

@noelle and to answer the other question people have: they can run the different stages of the drug trials almost simultaneously, that makes the process a lot faster. especially if you have a LOT of subjects and a LOT of opportunities to be infected.

@gzt @noelle I'm still waiting on J&J to do tests on immune compromised people that was scheduled for Q3. The moderna one done on people on immune suppressant drugs for organ transplants suggested that it may not function well.
hopkinsmedicine.org/news/newsr

This is often what people mean by "untested".

@gzt @noelle

Straight from the CDC

"People should be counseled about the unknown vaccine safety profile and effectiveness in immunocompromised populations, the potential for reduced immune responses, and the need to continue to follow current guidance to protect themselves against COVID-19." cdc.gov/vaccines/covid-19/clin

@gzt @noelle
This is why people like me, who are taking immuno-suppressive things to fight M.S. are likely dependent on herd immunity to defend against it. We don't know if it's going to work because it literally has gone untested in this population cohort.

@gzt @noelle People have been giving me shit for not getting the vaccine yet. They call me out for being afraid of a little bump and a couple days of sniffles.

I am worried it will trigger an immune system cascade because of the spike protein's impact on kidney associated smooth muscle tissue and put me in a wheel chair just like the covid-19 virus itself.

@gzt @noelle
I tell people how important is is for those with healthy response to the vaccine to get it because it protects so many on immune suppressant drugs. About 4% of the population is immune suppressed in America.
medscape.com/viewarticle/87129

These are people how may be unknowingly not able to develop immune response to covid and could be putting themselves at risk until they confirm it worked.

@gzt @noelle incomplete information like you are sharing is potentially putting people at risk.

@gzt @noelle I'm also taking stuff to help with crohn's disease. These have been shown to reduce the vaccine effeciacy by 50 to ~70% on a population level.

There's a good review of this here advisory.com/daily-briefing/20

This space is really scary for anyone who's in this situation because of how so much of this stuff was left untested.

I stay really well isolated because the last thing I want to do is become a host for it and become a mutation reservoir. sciencemag.org/news/2020/12/uk

Its miserable.

@gzt @noelle I've been using a mask since before anyone was known to be infected in the states.

Spending every free moment exploring how the gut microbiome might improve chances of safely turning on my immune system.

I'm litterally contemplating eating medically validated dog shit because of some findings that mTOR might give me the ability to be confident in the vaccine working. ncbi.nlm.nih.gov/pmc/articles/

Might make my own vaccine if this thing has a rebound during winter as vitamin D wanes.

@noelle That's actually good to know, kinda interesting

@ashwin_baindur As it happens, this is true of all of the available vaccines. If memory serves, it was Pfizer that was ready for testing in January 2020; AZ and Moderna were in testing within a month of that.

@noelle without casting doubt on your assertion, I recall that the vaccines were prepared with a variety of different technologies, including at least one that was absolutely new, hence I think that that particular belief may not be accurate.

@noelle if i term that my conspiracy theory soaked brother, he'll still come up with a new thing

@noelle Cool story. So where are the safe, approved versions of SARS vaccines? You seem to insinuate that they exist. And for "more than a decade" even.

Last year, the vast majority of them were still in pre-clinical trial, and only 2 of them in phase 1.

who.int/blueprint/priority-dis

@raucao @noelle SARS was easy to detect and disappeared quickly, so there weren't any patients to do trials on and no profit in developing the vaccines further.

@clacke @noelle Yes. But that doesn't change the fact that there wasn't a sufficiently trialed vaccine to base the new ones on, but plenty of issues that prevented them from progressing to later trial stages back then.

@raucao @noelle The expected minimum time from hey we have the sequence to trials done was 18 months and they expedited it by e.g. starting phase 3 before phase 2 was done, so they could get it done. I'm not aware of any plenty of issues.

@noelle @vfrmedia if SARS was so great why wasn't there a SARS tw—oh

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